Environmental (e)RNA advances the reliability of eDNA by predicting its age

Utilizing exome, genome, and Sanger sequencing, a recurrent frameshift EMC10 variant was recognized in affected people in a global cohort of consanguineous households. A number of households have been independently recognized and linked through Matchmaker Alternate and inside databases. We assessed the impact of the frameshift variant on EMC10 RNA and protein expression and evaluated EMC10 expression in regular human mind tissue utilizing immunohistochemistry.

A homozygous variant EMC10 c.287delG (Refseq NM_206538.3, p.Gly96Alafs*9) segregated with affected people in every household, who exhibited a phenotypic spectrum of mental incapacity (ID) and international developmental delay (GDD), variable seizures and variable dysmorphic options (elongated face, curly hair, cubitus valgus, and arachnodactyly). The variant arose on two founder haplotypes and ends in considerably lowered EMC10 RNA expression and an unstable truncated EMC10 protein.

RNA binding proteins (RBPs) are a big and various class of proteins that regulate all features of RNA biology. As RBP dysregulation has been implicated in numerous human issues, together with cancers and neurodegenerative illness, small molecule chemical probes that focus on particular person RBPs characterize helpful instruments for deciphering RBP perform and guiding the manufacturing of recent therapeutics. Whereas RBPs are sometimes considered tough-to-drug, the invention of numerous small molecules that focus on RBPs has spurred appreciable latest curiosity in new methods for RBP chemical probe discovery. Right here we evaluation present and rising applied sciences for top throughput RBP-small molecule screening that we anticipate will assist unlock the complete therapeutic potential of this thrilling protein class.

Right here, we describe an in depth protocol for the isolation of purified populations of viable spermatogenic cells derived from the non-human primate mannequin organism Macaca fascicularis (cynomolgus). Utilizing fluorescence-activated cell sorting (FACS), we describe strategies to isolate spermatogonia and first spermatocytes ranging throughout the sub-stages of meiosis prophase I. These cell populations can be utilized with quite a lot of downstream assays, together with single-cell approaches equivalent to RNA sequencing, chromatin immunoprecipitation, quantitative RT-PCR, and immunocytochemistry. For full particulars on the use and execution of this protocol, please consult with Lau et al. (2020).

Whereas nucleoside 5′-triphosphates are precursors for RNA in fashionable biology, the presumed issue of creating these triphosphates on Hadean Earth has brought about many prebiotic researchers to contemplate different activated species for the prebiotic synthesis of RNA. We report right here that nickel(II), within the presence of borate, offers substantial quantities (2-3%) of nucleoside 5′-triphosphates upon evaporative heating within the presence of urea, salts, and cyclic trimetaphosphate (CTMP). Additionally recovered are nucleoside 5′-diphosphates and nucleoside 5′-monophosphates, each seemingly arising from 5′-triphosphate intermediates.

The overall degree of 5′-phosphorylation is usually 30%. Borate enhances the regiospecificity of phosphorylation, with elevated quantities of different phosphorylated species seen in its absence. Experimentally supported paths are already out there to make nucleosides in environments more likely to have been current on Hadean Earth quickly after a midsized 10²¹ to 10²³ kg impactor, which might even have delivered nickel to the Hadean floor. Additional, sources of prebiotic CTMP proceed to be proposed. Thus, these outcomes fill in one of many few remaining steps wanted to demystify the prebiotic synthesis of RNA and help a steady mannequin from atmospheric elements to oligomeric RNA that’s missing solely a mechanism to acquire homochirality within the product RNA.

Xanthophyllomyces dendrorhous is a basidiomycete yeast that produces carotenoids, primarily astaxanthin. Astaxanthin is an natural pigment of economic curiosity resulting from its antioxidant and coloring properties. X. dendrorhous has a purposeful SREBP pathway, and the Sre1 protein is the SREBP homolog on this yeast. Nevertheless, how sterol regulatory component (Sre)1 promotes the biosynthesis of sterols and carotenoids in X. dendrorhous is unknown. On this work, comparative RNA-sequencing evaluation between modified X. dendrorhous strains which have an lively Sre1 protein and the WT was carried out to determine Sre1-dependent genes.

Total RNA from Human Adult Normal Tissue: Uterus
R1234274-50	Biochain	50 ug	EUR 178
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue 5 Donor Pool: Uterus: Cervix of uterus
R1234275-P	Biochain	50 ug	EUR 328
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue 5 Donor Pool: Uterus
R1234274-P	Biochain	50 ug	EUR 328
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Human Tumor Tissue: Uterus
P1235274	Biochain	1 mg	EUR 320
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Human Total PSA (t-PSA) ELISA Kit
PRB-5049-TOTAL	Cell Biolabs	96 assays	EUR 572

Total Protein from Human Adult Normal Tissue: Uterus
P1234274	Biochain	1 mg	EUR 214
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

RNA isolater Total RNA Extraction Reagent
R401-01	Vazyme	100 ml	EUR 133

Green RNA Lysis Kit 50
GREENE1-RNA	Next Advance	50pack	EUR 180
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RNA Lysis Kit 250
GREENE5-RNA	Next Advance	250pack	EUR 571
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Navy RNA Lysis Kit 50
NAVYE1-RNA	Next Advance	50pack	EUR 198
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RNA Lysis Kit 250
NAVYE5-RNA	Next Advance	250pack	EUR 651
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Pink RNA Lysis Kit 50
PINKE1-RNA	Next Advance	50pack	EUR 178
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RNA Lysis Kit 250
PINKE5-RNA	Next Advance	250pack	EUR 561
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 50
REDE1-RNA	Next Advance	50pack	EUR 192
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 250
REDE5-RNA	Next Advance	250pack	EUR 622
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 50
YELLOWE1-RNA	Next Advance	50pack	EUR 192
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 250
YELLOWE5-RNA	Next Advance	250pack	EUR 624
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Total RNA Extraction Kit
K2014005	Biochain	1 kit	EUR 344
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA Isolation Kit
P-9100	EpiGentek	50 samples	EUR 347.25
Description: The best epigenetics products

5E GREEN RNA Lysis Kit 100
GREEN5E100-RNA	Next Advance	100pack	EUR 386
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

5E GREEN RNA Lysis Kit 20
GREEN5E20-RNA	Next Advance	20pack	EUR 138
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 50
GREENR1-RNA	Next Advance	50pack	EUR 184
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 250
GREENR5-RNA	Next Advance	250pack	EUR 587
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

5E Navy RNA Lysis Kit 100
NAVY5E100-RNA	Next Advance	100pack	EUR 453
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

5E Navy RNA Lysis Kit 20
NAVY5E20-RNA	Next Advance	20pack	EUR 153
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 50
NAVYR1-RNA	Next Advance	50pack	EUR 202
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 250
NAVYR5-RNA	Next Advance	250pack	EUR 666
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

5E PINK RNA Lysis Kit 100
PINK5E100-RNA	Next Advance	100pack	EUR 380
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E PINK RNA Lysis Kit 20
PINK5E20-RNA	Next Advance	20pack	EUR 136
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 50
PINKR1-RNA	Next Advance	50pack	EUR 181
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 250
PINKR5-RNA	Next Advance	250pack	EUR 576
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 100
RED5E100-RNA	Next Advance	100pack	EUR 429
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 20
RED5E20-RNA	Next Advance	20pack	EUR 148
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 50
REDR1-RNA	Next Advance	50pack	EUR 195
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 250
REDR5-RNA	Next Advance	250pack	EUR 638
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 50
YELLOWR1-RNA	Next Advance	50pack	EUR 199
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 250
YELLOWR5-RNA	Next Advance	250pack	EUR 656
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Total Protein from Human Adult Normal Tissue: Uterus: Cervix
P1234275	Biochain	1 mg	EUR 214
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Adult Normal Tissue: Uterus: Corpus
P1234276	Biochain	1 mg	EUR 214
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Adult Normal Tissue: Uterus: Fundus
P1234278	Biochain	1 mg	EUR 214
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Human Total PSA (t-PSA) ELISA Kit
PRB-5049-TOTAL-5	Cell Biolabs	5 x 96 assays	EUR 2283

Total RNA from Rat Normal Tissue: Adipose
R1434003-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Bladder
R1434010-50	Biochain	50 ug	EUR 303
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Brain
R1434035-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Colon
R1434090-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Heart
R1434122-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Kidney
R1434142-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Liver
R1434149-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Lung
R1434152-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Ovary
R1434183-50	Biochain	50 ug	EUR 296
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Pancreas
R1434188-50	Biochain	50 ug	EUR 296
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Placenta
R1434200-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Rectum
R1434206-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Spleen
R1434246-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Stomach
R1434248-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Testis
R1434260-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Thymus
R1434264-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA Isolation Kit II
FATRS--001	Favorgen	100 preps	EUR 308

Total RNA Isolation Kit II
FATRS--050	Favorgen	50 preps	EUR 216

Total RNA ExtractionMini KitAnimal Tissues
FYG301-50P	Yeastern Biotech	50 Preps	Ask for price

Total RNA ExtractionMini KitAnimal Tissues
FYG302-100P	Yeastern Biotech	100 Preps	Ask for price

Total RNA ExtractionMini KitAnimal Tissues
FYG302-300P	Yeastern Biotech	300 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-100P	Yeastern Biotech	100 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-300P	Yeastern Biotech	300 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-50P	Yeastern Biotech	50 Preps	Ask for price

Total RNA Isolation Kit (Tissue)
P-9102	EpiGentek	50 samples	EUR 347.25
Description: reagents widely cited

Total RNA Isolation Kit (Plant)
P-9104	EpiGentek	50 samples	EUR 347.25
Description: kits suitable for this type of research

Total RNA from Lupus: Colon
R1236090Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Heart
R1236122Hd-2	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Kidney
R1236142Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Liver
R1236149Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Lung
R1236152Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Pancreas
R1236188Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Spleen
R1236246Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Stomach
R1236248Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

AnaPrep Total RNA Extraction Kit
Z1322015	Biochain	1 kit (48 extractions) Including all required plastic disposables	EUR 308
Description: This kit is developped for our fully automated magnetic bead-based nucleic acid extraction platform which uses preprogrammed protocols and can process up to 12 samples simultaneously. With the AnaPrep 12 Extractor you will have the option to choose and work with a wide range of sample and reagent volumes. This sturdy, realiable and user-friendly machine will save you both time and expenses while ensuring consistently high quality performance and nucleic acids for your downstream applications.

Total RNA from Rat Normal Tissue: Brain, cerebellum
R1434039-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Skeletal Muscle
R1434171-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Small Intestine
R1434226-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Plant Total RNA Mini Kit (50prep)
FAPRK-001	Favorgen	50 preps	EUR 165

Plant Total RNA Mini Kit (100prep)
FAPRK-001-1	Favorgen	100 preps	EUR 216

Plant Total RNA Mini Kit (300prep)
FAPRK-001-2	Favorgen	300 preps	EUR 404

Plant Total RNA Maxi Kit (10prep)
FAPRK-002	Favorgen	10 preps	EUR 201

Plant Total RNA Maxi Kit (24prep)
FAPRK-002-1	Favorgen	24 preps	EUR 317

Tissue Total RNA Mini Kit (50prep)
FATRK-001	Favorgen	50 preps	EUR 165

Tissue Total RNA Mini Kit (100prep)
FATRK-001-1	Favorgen	100 preps	EUR 216

Tissue Total RNA Mini Kit (300prep)
FATRK-001-2	Favorgen	300 preps	EUR 404

Tissue Total RNA Maxi Kit (10prep)
FATRK-003	Favorgen	10 preps	EUR 201

Tissue Total RNA Maxi Kit (24prep)
FATRK-003-1	Favorgen	24 preps	EUR 317

Total RNA ExtractionMini KitBlood/Cultured Cell
FYG301-300P	Yeastern Biotech	300 Preps	Ask for price

Broad Range Total RNA Isolation Kit
K1341050	Biochain	1 kit	EUR 266
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Alzheimer's Disease: Brain
R1236035Alz-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Pons
R1236071Alz-10	Biochain	10 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Colon
R1236090Dia-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Colon
R1236090Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Esophagus
R1236106Dia-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

As well as, Sre1 direct goal genes have been recognized by way of ChIP mixed with lambda exonuclease digestion (ChIP-exo) assays. SRE motifs have been detected within the promoter areas of a number of Sre1 direct goal genes and have been in line with the SREs described in different yeast species. Sre1 immediately regulates genes associated to ergosterol biosynthesis in addition to genes associated to the mevalonate (MVA) pathway, which synthesizes the constructing blocks of isoprenoids, together with carotenoids. Two carotenogenic genes, crtE and crtR, have been additionally recognized as Sre1 direct goal genes.